MOTS-C, hot sale, good quality and feedback from customers CAS NO.1627580-64-6

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Low MOQ:

Don't worry about the small order, our MOQ is one box for each product. For some, we can send 1-3vials for free, customer only need to pay the international shipping fee.

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1. Overview of MOTS-c

• Full Name: Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c)

• Origin: Encoded within the mitochondrial genome (12S rRNA region).

• Length: A 16-amino acid peptide.

• Discovery: Identified in 2015 by Lee et al. as a biologically active mitochondrial-derived peptide.

2. Biological Functions

MOTS-c plays a critical role in metabolic regulation and cellular stress response. Key functions include:

Metabolic Regulation

• Glucose Homeostasis: MOTS-c enhances glucose uptake and utilization in skeletal muscle, improving insulin sensitivity.

• Fat Metabolism: It promotes fatty acid oxidation and reduces fat accumulation, potentially combating obesity.

• AMPK Activation: MOTS-c activates AMP-activated protein kinase (AMPK), a key energy sensor that regulates cellular metabolism.

Anti-Aging and Cellular Protection

• Oxidative Stress: MOTS-c reduces oxidative stress by enhancing the cellular antioxidant defense system.

• Mitochondrial Function: It supports mitochondrial biogenesis and function, which is critical for energy production and cellular health.

• Inflammation: MOTS-c has anti-inflammatory properties, potentially mitigating chronic inflammation associated with aging and metabolic disorders.

Exercise Mimetic

• MOTS-c is often referred to as an "exercise mimetic" because it mimics some of the beneficial effects of physical exercise, such as improved metabolic health and endurance.

3. Mechanisms of Action

• Nuclear Translocation: MOTS-c can translocate to the nucleus under stress conditions and regulate gene expression, particularly genes involved in metabolism and stress response.

• AMPK Pathway: It activates AMPK, which in turn regulates energy homeostasis and metabolic pathways.

• Folate Cycle Regulation: MOTS-c interacts with the folate-methionine cycle, influencing one-carbon metabolism and cellular redox balance.

4. Potential Applications

MOTS-c has significant therapeutic potential, particularly in the following areas:

Metabolic Disorders

• Type 2 Diabetes: Improves insulin sensitivity and glucose metabolism.

• Obesity: Promotes fat oxidation and reduces adiposity.

Aging and Age-Related Diseases

• Anti-Aging: Enhances mitochondrial function and reduces oxidative stress, potentially slowing aging processes.

• Neurodegenerative Diseases: May protect against diseases like Alzheimer's by reducing oxidative stress and inflammation.

Muscle and Physical Performance

• Exercise Mimicry: Could be used to improve physical performance and recovery, especially in individuals unable to exercise.

Other Applications

• Cardiovascular Health: May protect against heart disease by improving metabolic health and reducing inflammation.

• Cancer: Emerging research suggests a role in cancer metabolism, though this area is still under investigation.

5. Research Challenges

While MOTS-c shows great promise, there are challenges to address:

• Delivery Systems: Developing effective methods to deliver MOTS-c in vivo (e.g., peptide stability, bioavailability).

• Long-Term Effects: Understanding the long-term safety and efficacy of MOTS-c supplementation.

• Mechanistic Details: Further elucidating its molecular mechanisms and interactions with other pathways.

6. Current Research Directions

• Clinical Trials: Investigating the therapeutic potential of MOTS-c in humans (e.g., for metabolic syndrome, aging, and exercise performance).

• Synthetic Analogs: Developing more stable and potent analogs of MOTS-c for therapeutic use.

• Biomarker Potential: Exploring MOTS-c as a biomarker for metabolic health and aging.

7. Tools and Techniques for Studying MOTS-c

• Peptide Synthesis: Solid-phase peptide synthesis (SPPS) to produce MOTS-c and its analogs.

• In Vitro Models: Cell cultures to study MOTS-c's effects on metabolism, mitochondrial function, and stress responses.

• In Vivo Models: Animal studies (e.g., mice) to evaluate metabolic and anti-aging effects.

• Omics Approaches: Transcriptomics, proteomics, and metabolomics to understand MOTS-c's systemic effects.